| Date | Home | Result | Away | |
| 26-12-20 | Southport | 2 - 2 |
Curzon Ashton | |
| 12-12-20 | Guiseley | 4 - 2 |
Southport | |
| 05-12-20 | Southport | 1 - 1 |
Alfreton Town | |
| 02-12-20 | Southport | 0 - 1 |
Farsley Celtic | |
| 21-11-20 | Gateshead | 4 - 1 |
Southport | |
| 17-11-20 | Bradford Park Avenue | 0 - 2 |
Southport | |
| 14-11-20 | Southport | 0 - 2 |
Spennymoor Town | |
| 10-11-20 | Southport | 2 - 3 |
York City | |
| 07-11-20 | AFC Telford United | 1 - 1 |
Southport | |
| 03-11-20 | Kettering Town | 0 - 1 |
Southport | |
| 31-10-20 | Southport | 0 - 1 |
Boston United | |
| 24-10-20 | Blyth Spartans | 0 - 3 |
Southport | |
| 17-10-20 | Southport | 1 - 0 |
Chorley | |
| 06-10-20 | Southport | 0 - 0 |
Hereford FC |